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Indian J Exp Biol ; 2001 Dec; 39(12): 1302-4
Article in English | IMSEAR | ID: sea-55625

ABSTRACT

Nine extracts of H. perforatum, containing hyperforin in conjugated forms, but devoid of free hyperforin and adhyperforin, were subjected to antidepressant screening using the forced swim test (FST). The observed activity was compared with that of SJW extracts containing hyperforin and adhyperforin (in free form). Results indicate that hyperforin conjugates exhibit significant antidepressant activity as evidenced by the reduced immobility period in the FST in rats.


Subject(s)
Animals , Antidepressive Agents/isolation & purification , Bridged Bicyclo Compounds , Female , Hypericum/chemistry , Male , Phloroglucinol/analogs & derivatives , Plant Extracts/pharmacology , Rats , Swimming , Terpenes/isolation & purification
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